Hyperacusis Treatment Report

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Acoustic startle stimuli inhibit pain but do not alter nociceptive flexion reflexes to sural nerve stimulation

https://pubmed.ncbi.nlm.nih.gov/33448016/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20210115123914&v=2.14.2

TITLE:
Acoustic startle stimuli inhibit pain but do not alter nociceptive flexion reflexes to sural nerve stimulation

DESCRIPTION:
Acoustic startle stimuli inhibit pain, but whether this is due to a cross-modal inhibitory process or some other mechanism is uncertain. To investigate this, electrical stimulation of the sural nerve either preceded or followed an acoustic startle stimulus (by 200 ms) or was presented alone in 30 healthy participants. Five electrical stimuli, five acoustic startle stimuli, 10 startle + electrical stimuli, and 10 electrical + startle stimuli were presented in mixed order at intervals of 30-60 s….

PMID:
pubmed:33448016

DATE FOUND:
01/15/21 12:39PM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/33448016/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20210115123914&v=2.14.2

https://onlinelibrary.wiley.com/doi/10.1111/psyp.13757

Role of Exposure in Hyperacusis

https://clinicaltrials.gov/ct2/show/NCT04705246?type=Intr&cond=Hyperacusis&lupd_s=12%2F29%2F2020&lupd_d=14&sort=nwst

STUDY TITLE:
Role of Exposure in Hyperacusis

DESCRIPTION:
Condition:   Hyperacusis
Intervention:   Behavioral: Psychoeducation
Sponsors:   University Hospital, Antwerp;   Universiteit Antwerpen
Recruiting

CLINICALTRIALS.GOV IDENTIFIER:
NCT04705246

FIRST POSTED:
Tue, 12 Jan 2021 12:00:00 EST

LAST UPDATE POSTED:
01/12/21 06:49AM

STUDY LINK / URL:
https://clinicaltrials.gov/ct2/show/NCT04705246?type=Intr&cond=Hyperacusis&lupd_s=12%2F29%2F2020&lupd_d=14&sort=nwst

A psychoacoustic test for diagnosing hyperacusis based on ratings of natural sounds

https://www.sciencedirect.com/science/article/abs/pii/S0378595520303956?via%3Dihub

https://pubmed.ncbi.nlm.nih.gov/33321385/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201216004020&v=2.13.0

TITLE:
A psychoacoustic test for diagnosing hyperacusis based on ratings of natural sounds

DESCRIPTION:
Hyperacusis is defined as an increased sensitivity to sounds, i.e. sounds presented at moderate levels can produce discomfort or even pain. Existing diagnostic methods, like the Hyperacusis Questionnaire (HQ) and Loudness Discomfort Levels (LDLs), have been challenged because of their variability and lack of agreement on appropriate cut-off values. We propose a novel approach by using psychoacoustic ratings of natural sounds as an assessment tool for hyperacusis. Subjects (n = 81) were presented…

PMID:
pubmed:33321385

DATE FOUND:
12/16/20 12:48AM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/33321385/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201216004020&v=2.13.0

A Delphi survey to determine a definition and description of hyperacusis by clinician consensus

CATEGORY:
Research

TITLE:
A Delphi survey to determine a definition and description of hyperacusis by clinician consensus

DESCRIPTION:
CONCLUSIONS: This consensus definition of hyperacusis will help to determine the scope of clinical practice guidelines and influence needed research on hyperacusis.

CONTENT:
Int J Audiol. 2020 Dec 11:1-7. doi: 10.1080/14992027.2020.1855370. Online ahead of print.

ABSTRACT

OBJECTIVE: There is currently no singularly accepted definition of hyperacusis. The aim of this study was to determine a definition and description of hyperacusis by clinician consensus.

DESIGN: A three-round Delphi survey involving hearing healthcare professionals built towards clinical consensus on a definition of hyperacusis. Round 1 involved three open-ended questions about hyperacusis. Seventy-nine statements were generated on descriptions, impact, sounds, and potential features of hyperacusis. Agreement on the relevance of each statement to defining or describing hyperacusis was then measured in Rounds 2 and 3. General consensus was defined a priori as ≥70% agreement, or ≥90 for clinical decision making.

STUDY SAMPLE: Forty-five hearing healthcare professionals were recruited to take part in this study. Forty-one completed Round 1, 36 completed Round 2, and 33 completed Round 3.

RESULTS: Consensus was reached on 42/79 statements. From these a consensus definition includes “A reduced tolerance to sound(s) that are perceived as normal to the majority of the population or were perceived as normal to the person before their onset of hyperacusis”. A consensus description of hyperacusis was also determined.

CONCLUSIONS: This consensus definition of hyperacusis will help to determine the scope of clinical practice guidelines and influence needed research on hyperacusis.

PMID:33305628 | DOI:10.1080/14992027.2020.1855370

SOURCE:
International journal of audiology

DATE – PUBLISHED:
2020-12-11T23:03:03Z

DATE – DOI: 2020-12-11T23:03:03Z
DATE – PUBMED: 2020 Dec 11
DATE OUTPUT MATCHED: True

DATE – ADDED:
Fri, 11 Dec 2020 06:00:00 -0500

DATE – RETRIEVED:
12/11/20 11:39PM
2020-12-11T23:39:29-05:00

IDENTIFIER:
pmid:33305628,doi:10.1080/14992027.2020.1855370

PUBMED ID:
pubmed:33305628

DOI:
10.1080/14992027.2020.1855370

LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/33305628/

LINK – DOI:
https://doi.org/10.1080/14992027.2020.1855370

LINK – PUBLISHER:
https://www.tandfonline.com/doi/full/10.1080/14992027.2020.1855370

REFERENCES:
Hyperacusis Treatment Report, Urgent Research, 2020-12-11T23:39:29-05:00, https://www.hyperacusistreatmentreport.com.

Internal Consistency and Convergent Validity of the Inventory of Hyperacusis Symptoms

https://pubmed.ncbi.nlm.nih.gov/33259445/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201201182308&v=2.13.0

TITLE:
Internal Consistency and Convergent Validity of the Inventory of Hyperacusis Symptoms

DESCRIPTION:
CONCLUSIONS: The IHS has good internal consistency and reasonably high convergent validity, as indicated by the relationship of IHS scores to HQ scores and ULLs, but IHS scores may also partly reflect the co-occurrence of tinnitus, anxiety, and depression. We propose an IHS cutoff score of 56 instead of 69 for diagnosing hyperacusis.

PMID:
pubmed:33259445

DATE FOUND:
12/01/20 06:23PM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/33259445/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201201182308&v=2.13.0

Bushy cells may contribute to the neural basis of hyperacusis, according to new research from Dr. Susan Shore

Abstract from a new Susan Shore paper published in Scientific Reports (Nature) on November 26, 2020:

Psychophysical studies characterize hyperacusis as increased loudness growth over a wide-frequency range, decreased tolerance to loud sounds and reduced behavioral reaction time latencies to high-intensity sounds. While commonly associated with hearing loss, hyperacusis can also occur without hearing loss, implicating the central nervous system in the generation of hyperacusis. Previous studies suggest that ventral cochlear nucleus bushy cells may be putative neural contributors to hyperacusis. Compared to other ventral cochlear nucleus output neurons, bushy cells show high firing rates as well as lower and less variable first-spike latencies at suprathreshold intensities. Following cochlear damage, bushy cells show increased spontaneous firing rates across a wide-frequency range, suggesting that they might also show increased sound-evoked responses and reduced latencies to higher-intensity sounds. However, no studies have examined bushy cells in relationship to hyperacusis. Herein, we test the hypothesis that bushy cells may contribute to the neural basis of hyperacusis by employing noise-overexposure and single-unit electrophysiology. We find that bushy cells exhibit hyperacusis-like neural firing patterns, which are comprised of enhanced sound-driven firing rates, reduced first-spike latencies and wideband increases in excitability.

Read the full paper here:

https://www.nature.com/articles/s41598-020-77754-z

Also, keep an eye on those bushy cells…

“Bushy cells are part of an electrotonically-coupled network that may allow for the rapid spread of excitation.”

Apparently they might be linked to tinnitus and, considering their role in the visual cortex, maybe even visual snow syndrome.

That’s all for now.

To get updates on the latest hyperacusis research and potential treatments, subscribe to the free email newsletter.

Within-Subject Comparisons of the Auditory Brainstem Response and Uncomfortable Loudness Levels in Ears With and Without Tinnitus in Unilateral Tinnitus Subjects With Normal Audiograms

https://pubmed.ncbi.nlm.nih.gov/33177407/

https://journals.lww.com/otology-neurotology/Abstract/9000/Within_Subject_Comparisons_of_the_Auditory.95926.aspx

Within-Subject Comparisons of the Auditory Brainstem Response and Uncomfortable Loudness Levels in Ears With and Without Tinnitus in Unilateral Tinnitus Subjects With Normal Audiograms

No Studies found for: Hyperacusis (October 1, 2020)

https://clinicaltrials.gov/ct2/results?cond=Hyperacusis&term=&type=Intr&rslt=&age_v=&gndr=&intr=&titles=&outc=&spons=&lead=&id=&cntry=&state=&city=&dist=&locn=&strd_s=&strd_e=&prcd_s=&prcd_e=&sfpd_s=&sfpd_e=&lupd_s=&lupd_e=&sort=nwst

No Studies found for: Hyperacusis (October 1, 2020)

The Content and Quality of Information About Hyperacusis Presented Online

https://pubs.asha.org/doi/10.1044/2020_AJA-19-00074

https://pubmed.ncbi.nlm.nih.gov/32946248/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200918185324&v=2.11.5

TITLE:
The Content and Quality of Information About Hyperacusis Presented Online

DESCRIPTION:
Purpose Hyperacusis is a disorder characterized by reduced sound tolerance leading to ear pain, emotional distress, and reduced quality of life. Many people with hyperacusis turn to the Internet for information and support from online communities to discuss their condition. The purpose of this study was to assess the content and quality of hyperacusis information presented online. Method The three most used Internet search engines were used to identify relevant websites using the single search…

PMID:
pubmed:32946248

DATE FOUND:
09/18/20 06:53PM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32946248/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200918185324&v=2.11.5

A Novel Mouse Model of Aminoglycoside-Induced Hyperacusis and Tinnitus

https://www.frontiersin.org/articles/10.3389/fnins.2020.561185/full

https://pubmed.ncbi.nlm.nih.gov/33041759/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201012071633&v=2.12.3

TITLE:
A Novel Mouse Model of Aminoglycoside-Induced Hyperacusis and Tinnitus

DESCRIPTION:
Aminoglycosides (AG) such as amikacin are commonly used in cystic fibrosis patients with opportunistic pulmonary infections including multi-drug resistant mycobacterium tuberculous and non-tuberculous mycobacterium. Unfortunately, this class of drugs is known to cause peripheral damage to the cochlea leading to hearing loss that can fluctuate and become permanent over time or multiple exposures. However, whether amikacin can lead to central auditory dysfunction like hyperacusis (increased…

PMID:
pubmed:33041759

DATE FOUND:
10/12/20 07:16AM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/33041759/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201012071633&v=2.12.3

Investigation of Mechanisms in Bone Conduction Hyperacusis With Third Window Pathologies Based on Model Predictions

https://www.frontiersin.org/articles/10.3389/fneur.2020.00966/full

https://pubmed.ncbi.nlm.nih.gov/32982955/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200929171732&v=2.11.5

TITLE:
Investigation of Mechanisms in Bone Conduction Hyperacusis With Third Window Pathologies Based on Model Predictions

DESCRIPTION:
A lumped element impedance model of the inner ear with sources based on wave propagation in the skull bone was used to investigate the mechanisms of hearing sensitivity changes with semi-circular canal dehiscence (SSCD) and alterations of the size of the vestibular aqueduct. The model was able to replicate clinical and experimental findings reported in the literature. For air conduction, the reduction in cochlear impedance due to a SSCD reduces the intra-cochlear pressure at low frequencies…

PMID:
pubmed:32982955

DATE FOUND:
09/29/20 05:17PM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32982955/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200929171732&v=2.11.5

The Role of Anti-Endothelial Cell Autoantibodies and Immune Response in Acute Low-Tone Hearing Loss

https://pubmed.ncbi.nlm.nih.gov/32865463/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200831191109&v=2.11.5

TITLE:
The Role of Anti-Endothelial Cell Autoantibodies and Immune Response in Acute Low-Tone Hearing Loss

DESCRIPTION:
CONCLUSION: The results supported that AECAs might wield influence on the short-term outcome of acute low-tone hearing loss (ALHL) treatment. Furthermore, AECA-mediated acute low-frequency hearing loss possibly involved dysregulation of inflammation process and release of cytokines.

PMID:
pubmed:32865463

DATE FOUND:
08/31/20 07:11PM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32865463/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200831191109&v=2.11.5

No Studies found for: Hyperacusis (August 12, 2020)

https://clinicaltrials.gov/ct2/results?cond=Hyperacusis&term=&type=Intr&rslt=&recrs=b&recrs=a&recrs=f&recrs=d&age_v=&gndr=&intr=&titles=&outc=&spons=&lead=&id=&cntry=&state=&city=&dist=&locn=&phase=4&phase=0&phase=1&phase=2&phase=3&rsub=&strd_s=&strd_e=&prcd_s=&prcd_e=&sfpd_s=&sfpd_e=&rfpd_s=&rfpd_e=&lupd_s=&lupd_e=&sort=nwst

Acoustic Reflexes in Individuals Having Hyperacusis of the Auditory Origin

https://link.springer.com/article/10.1007%2Fs12070-020-02002-9

https://pubmed.ncbi.nlm.nih.gov/33088781/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201022064939&v=2.12.6

TITLE:
Acoustic Reflexes in Individuals Having Hyperacusis of the Auditory Origin

DESCRIPTION:
Functional role of the acoustic reflex in preventing over stimulation of the inner auditory system by decreasing sound intensity along with the previous reports of acoustic reflex abnormalities in individuals having hyperacusis point towards the involvement of acoustic reflex deficit in the origin of hyperacusis especially when any medical condition leading to hyperacusis is not associated. However this issue remains contradictory owing to limited comprehensive investigation. This study was…

PMID:
pubmed:33088781

DATE FOUND:
10/22/20 06:49AM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/33088781/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201022064939&v=2.12.6

Association between Hyperacusis and Tinnitus

https://www.mdpi.com/2077-0383/9/8/2412/htm

https://pubmed.ncbi.nlm.nih.gov/32731492/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200731120853&v=2.11.4

TITLE:
Association between Hyperacusis and Tinnitus

DESCRIPTION:
Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18-90 years, and provided information on socio-demographic characteristics, as well as presence of…

PMID:
pubmed:32731492

DATE FOUND:
07/31/20 12:08PM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32731492/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200731120853&v=2.11.4

The World Is Noisy. These Groups Want to Restore the Quiet

https://www.wired.com/story/the-world-is-noisy-these-groups-want-to-restore-the-quiet/

The World Is Noisy. These Groups Want to Restore the Quiet
Silence is increasingly scarce, even in national parks. Now, scientists and environmentalists are working to calm the noise for the good of nature—and for us.

Functional Neuroanatomy of Salicylate- and Noise-Induced Tinnitus and Hyperacusis

https://link.springer.com/chapter/10.1007%2F7854_2020_156

https://pubmed.ncbi.nlm.nih.gov/32653998/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200713031059&v=2.10.1

TITLE:
Functional Neuroanatomy of Salicylate- and Noise-Induced Tinnitus and Hyperacusis

DESCRIPTION:
Tinnitus and hyperacusis are debilitating conditions often associated with aging or exposure to intense noise or ototoxic drugs. One of the most reliable methods of inducing tinnitus is with high doses of sodium salicylate, the active ingredient in aspirin. High doses of salicylate have been widely used to investigate the functional neuroanatomy of tinnitus and hyperacusis. High doses of salicylate have been used to develop novel behavioral methods to detect the presence of tinnitus and…

PMID:
pubmed:32653998

DATE FOUND:
07/13/20 03:11AM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32653998/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200713031059&v=2.10.1

The sound-sensitive tinnitus index: Psychometric properties of a scale to assess the impact of tinnitus exacerbated by sound

http://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2019;volume=21;issue=100;spage=98;epage=107;aulast=Greenberg

https://pubmed.ncbi.nlm.nih.gov/32655063/

https://pubmed.ncbi.nlm.nih.gov/32655063/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200713131322&v=2.10.1

TITLE:
The sound-sensitive tinnitus index: Psychometric properties of a scale to assess the impact of tinnitus exacerbated by sound

DESCRIPTION:
CONCLUSIONS: As a valid and reliable measure, the SSTI fills an important gap as a clinical and research tool that can differentiate and assess severity and treatment progress in manifestations of combined tinnitus and auditory sensitivity symptoms.

PMID:
pubmed:32655063

DATE FOUND:
07/13/20 01:13PM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32655063/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200713131322&v=2.10.1

Hyperacusis in children: a scoping review

https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-020-02223-5

https://pubmed.ncbi.nlm.nih.gov/32600446/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200630064428&v=2.9.4

TITLE:
Hyperacusis in children: a scoping review

DESCRIPTION:
CONCLUSION: The information we catalogued on various elements of clinical profile, assessment and management can serve as a stepping stone in future research developing questionnaires for clinical measurement of the impact of hyperacusis on children, and the measurement of treatment related change in clinic and in trials. Positive outcomes were noted by the authors following all of the above treatments; future research must compare these and specify the parameters for optimal results.

PMID:
pubmed:32600446

DATE FOUND:
06/30/20 06:44AM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32600446/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200630064428&v=2.9.4

No Studies found for: Hyperacusis (June 27, 2020)

https://clinicaltrials.gov/ct2/results?cond=Hyperacusis&term=&type=Intr&rslt=&recrs=b&recrs=a&recrs=f&recrs=d&age_v=&gndr=&intr=&titles=&outc=&spons=&lead=&id=&cntry=&state=&city=&dist=&locn=&phase=4&phase=0&phase=1&phase=2&phase=3&rsub=&strd_s=&strd_e=&prcd_s=&prcd_e=&sfpd_s=&sfpd_e=&rfpd_s=&rfpd_e=&lupd_s=&lupd_e=&sort=nwst

No Studies found for: Recruiting, Not yet recruiting, Active, not recruiting, Enrolling by invitation Studies | Interventional Studies | Hyperacusis | Phase Early Phase 1, 1, 2, 3, 4

Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling

https://www.sciencedirect.com/science/article/abs/pii/S0378595520302835?via%3Dihub

https://pubmed.ncbi.nlm.nih.gov/32554129/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200623165251&v=2.9.2

TITLE:
Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling

DESCRIPTION:
Moderate intensity sounds can reduce pain sensitivity (i.e., audio-analgesia) whereas intense sounds can induce aural pain, evidence of multisensory interaction between auditory and pain pathways. To explore auditory-pain pathway interactions, we used the tail-flick (TF) test to assess thermal tail-pain sensitivity by measuring the latency of a rat to remove its tail from 52 °C water. In Experiment 1, TF latencies were measured in ambient noise and broadband noise (BBN) presented from 80 to 120…

PMID:
pubmed:32554129

DATE FOUND:
06/23/20 04:55PM

LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32554129/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200623165251&v=2.9.2

Correlation between recovery time of extended high-frequency audiometry and duration of inflammation in patients with acute otitis media

https://link.springer.com/article/10.1007%2Fs00405-020-05973-1

https://www.ncbi.nlm.nih.gov/pubmed/32333137?dopt=Abstract

TITLE:
Correlation between recovery time of extended high-frequency audiometry and duration of inflammation in patients with acute otitis media.

DESCRIPTION:
Related Articles

Correlation between recovery time of extended high-frequency audiometry and duration of inflammation in patients with acute otitis media.

Eur Arch Otorhinolaryngol. 2020 Apr 24;:

Authors: Li G, Li T, Liu H, Sun L

Abstract

OBJECTIVES: To explore the rule of extended high-frequency (EHF) audiometry recovery in patients with acute otitis media.

METHODS: From January 2016 to July 2019, patients with acute otitis media in the outpatient department of otology were studied. The diagnosis was made according to the otoscopy and acoustic impedance tests, and antibiotics and other treatment programs were given. The patients were followed up to compare the effects of different recovery time on extended high-frequency audiometry in patients with acute otitis media.

RESULTS: 146 patients with acute otitis media (69 in the left ear and 77 in the right ear) were selected for observation and follow-up. The patients were divided into three groups according to the time from the onset to the disappearance of hyperacusis and earache symptoms: ≤ 5 days group (26 patients, 17.8%), 6-10 days group (74 patients, 50.7%), and > 10 days group (46 patients, 31.5%). The threshold of EHF in the study group was significantly higher than that in the control group in the early stage. According to the study design for follow-up, we found that with the prolongation of the duration of acute otitis media, the extended high frequency of different groups had different changes.

CONCLUSIONS: Our results show that the recovery time of EHF in patients with acute otitis media was later than that of the standard audiogram and was closely related to the course of the disease. This is of great significance for discovering the hidden hearing loss of the patients and taking the treatment plan as soon as possible.

PMID: 32333137 [PubMed – as supplied by publisher]

PMID:
PubMed:32333137

DATE FOUND:
04/26/20 06:04AM

LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/32333137?dopt=Abstract

No Studies found for: Hyperacusis (January 20, 2020)

https://clinicaltrials.gov/ct2/results?cond=Hyperacusis&term=&type=Intr&rslt=&age_v=&gndr=&intr=&titles=&outc=&spons=&lead=&id=&cntry=&state=&city=&dist=&locn=&strd_s=&strd_e=&prcd_s=&prcd_e=&sfpd_s=&sfpd_e=&lupd_s=&lupd_e=&sort=nwst

No Studies found for: Hyperacusis (January 20, 2020)

Hearing Study: Sensitivity to Features of Speech Sounds

https://clinicaltrials.gov/ct2/show/NCT03666676

Hearing Study: Sensitivity to Features of Speech Sounds

Study Description

Brief Summary:
The purpose of this study is to better understand the sensitivity of listeners to the fast changes in frequency or amplitude of sounds that occur in speech. The investigators are studying ways to manipulate these aspects of sounds in an effort to make speech sounds more clear.

Condition or disease Intervention/treatment Phase
Hearing Loss, Sensorineural
Other: Signal processing to improve intelligibility
Not Applicable

Detailed Description:
The investigators will test listeners with normal hearing or with mild or moderate hearing loss. Tests will first focus on sensitivity to changes in fast changes in amplitude (loudness) or frequency (pitch) in sounds. Then the investigators will test the intelligibility of synthetic vowels and syllables in which these “chirps” are manipulated. Finally, the investigators will test intelligibility of words in noise while manipulating sounds in an effort to improve clarity.
Study Design
Go to sections
Study Type : Interventional (Clinical Trial)
Estimated Enrollment : 200 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Auditory Processing of Complex Sounds – Sensitivity to Chirps
Actual Study Start Date : January 15, 2020
Estimated Primary Completion Date : November 30, 2023
Estimated Study Completion Date : November 30, 2023

Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients

https://journals.sagepub.com/doi/abs/10.1177/0003489419892997?journalCode=aora

https://pubmed.ncbi.nlm.nih.gov/31786960-efficacy-of-multi-modal-migraine-prophylaxis-therapy-on-hyperacusis-patients/

Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients

PMID: 31786960

Abstract

Objectives:
To evaluate the efficacy of a multi-modal migraine prophylaxis therapy for patients with hyperacusis.

Methods:
In a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen (nortriptyline, verapamil, topiramate, or a combination thereof) as well as lifestyle and dietary modifications. Pre- and post-treatment average loudness discomfort level (LDL), hyperacusis discomfort level measured by a visual analogue scale (VAS), and scores on the modified Khalfa questionnaire for severity of hyperacusis were compared.

Results:
Twenty-two of the 25 patients (88%) reported subjective resolution of their symptoms following treatment. Post-treatment audiograms showed significant improvement in average LDL from 81.3 ± 3.2 dB to 86.4 ± 2.6 dB (P < .001), indicating increased sound tolerability. The VAS discomfort level also showed significant improvement from a pre-treatment average of 7.7 ± 1.1 to 3.7 ± 1.6 post-treatment (P < .001). There was also significant improvement in the average total score on modified Khalfa questionnaire (32.2 ± 3.6 vs 22.0 ± 5.7, P < .001). Conclusions: The majority of patients with hyperacusis demonstrated symptomatic improvement from migraine prophylaxis therapy, as indicated by self-reported and audiometric measures. Our findings indicate that, for some patients, hyperacusis may share a pathophysiologic basis with migraine disorder and may be successfully managed with multimodal migraine prophylaxis therapy.

Clinical Advancements for Managing Hyperacusis with Pain

https://journals.lww.com/thehearingjournal/Fulltext/2019/10000/Clinical_Advancements_for_Managing_Hyperacusis.4.aspx

Clinical Advancements for Managing Hyperacusis with Pain
Pollard, Bryan
Author Information
Mr. Pollard is the founder of Hyperacusis Research, a non-profit that focuses on uncovering the mechanisms of hyperacusis to eliminate noise-induced pain. He is also a manager and technical problem-solver in engineering disciplines associated with complex processes.

A review of auditory gain, low-level noise and sound therapy for tinnitus and hyperacusis

https://www.tandfonline.com/doi/abs/10.1080/14992027.2019.1660812?journalCode=iija20

https://www.ncbi.nlm.nih.gov/pubmed/31498009?dopt=Abstract

TITLE:
A review of auditory gain, low-level noise and sound therapy for tinnitus and hyperacusis.

DESCRIPTION:
Related Articles

A review of auditory gain, low-level noise and sound therapy for tinnitus and hyperacusis.

Int J Audiol. 2019 Sep 09;:1-11

Authors: Sheppard A, Stocking C, Ralli M, Salvi R

Abstract

Objective: This article reviews: (1) the evidence related to enhanced central gain as a potential mechanism for the generation of tinnitus and hyperacusis, (2) the neuroplastic changes induced by prolonged, low-level sound stimulation and (3) the clinical effectiveness of various sound therapies and amplification for the treatment of tinnitus and hyperacusis. Design: General literature review. Study sample: Peer-reviewed articles related to auditory neural gain, prolonged low-level noise exposure and effectiveness of sound therapy. Results: A large body of literature exists supporting the enhanced neural gain model of tinnitus and hyperacusis. Neuroplastic changes associated with prolonged low-level noise show evidence of reversing enhanced neural gain, which should theoretically reduce percepts of tinnitus and/or hyperacusis. However, the available clinical evidence assessing the efficacy of sound therapy to reduce tinnitus or hyperacusis lacks controlled clinical trials to accurately assess the effectiveness of sound therapy. Conclusions: The available literature from basic science studies supports the neural gain model of tinnitus and hyperacusis, which conceivably should be effectively managed with sound therapy. However, well-controlled clinical trials are needed before conclusions can be made on the effectiveness of sound therapy for tinnitus and hyperacusis.

PMID: 31498009 [PubMed – as supplied by publisher]

PMID:
PubMed:31498009

DATE FOUND:
09/23/19 11:58AM

LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/31498009?dopt=Abstract

Testing the Central Gain Model: Loudness Growth Correlates With Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis

https://pubmed.ncbi.nlm.nih.gov/30292765-testing-the-central-gain-model-loudness-growth-correlates-with-central-auditory-gain-enhancement-in-a-rodent-model-of-hyperacusis/?from_term=%22Auditory+Cortex%2Fdrug+effects%22%5BMeSH%5D&from_sort=date&from_sort_order=&from_size=200&from_pos=2

https://www.sciencedirect.com/science/article/abs/pii/S0306452218306419?via%3Dihub

Neuroscience, 407, 93-107
2019 May 21

Testing the Central Gain Model: Loudness Growth Correlates With Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis

Benjamin D Auerbach 1, Kelly Radziwon 2, Richard Salvi 2

Affiliations
Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY 14214, USA. Electronic address: bda5@buffalo.edu.

PMID: 30292765 DOI: 10.1016/j.neuroscience.2018.09.036

Abstract
The central gain model of hyperacusis proposes that loss of auditory input can result in maladaptive neuronal gain increases in the central auditory system, leading to the over-amplification of sound-evoked activity and excessive loudness perception. Despite the attractiveness of this model, and supporting evidence for it, a critical test of the central gain theory requires that changes in sound-evoked activity be explicitly linked to perceptual alterations of loudness. Here we combined an operant conditioning task that uses a subject’s reaction time to auditory stimuli to produce reliable measures of loudness growth with chronic electrophysiological recordings from the auditory cortex and inferior colliculus of awake, behaviorally-phenotyped animals. In this manner, we could directly correlate daily assessments of loudness perception with neurophysiological measures of sound encoding within the same animal. We validated this novel psychophysical-electrophysiological paradigm with a salicylate-induced model of hearing loss and hyperacusis, as high doses of sodium salicylate reliably induce temporary hearing loss, neural hyperactivity, and auditory perceptual disruptions like tinnitus and hyperacusis. Salicylate induced parallel changes to loudness growth and evoked response-intensity functions consistent with temporary hearing loss and hyperacusis. Most importantly, we found that salicylate-mediated changes in loudness growth and sound-evoked activity were correlated within individual animals. These results provide strong support for the central gain model of hyperacusis and demonstrate the utility of using an experimental design that allows for within-subject comparison of behavioral and electrophysiological measures, thereby making inter-subject variability a strength rather than a limitation.

Keywords: auditory reaction time; central gain enhancement; hyperacusis; local field potentials; sodium salicylate.

Copyright © 2018. Published by Elsevier Ltd.

Influence of serotonergic depletion in nucleus accumbens (NAcc) on the startle reflex and hyperacusis

https://www.ncbi.nlm.nih.gov/pubmed/30970270?dopt=Abstract

https://www.sciencedirect.com/science/article/abs/pii/S0304394019300527?via%3Dihub

TITLE:
Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?

DESCRIPTION:
Related Articles

Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?

Neurosci Lett. 2019 07 13;705:246-250

Authors: Farahani S, Nasirinezhad F, Danyali S, Jalaei S, Shahbazi A, Karimi M, Mokrian H

Abstract

Hyperacusis may be defined as diminishing tolerance to moderate and high intensity sounds in people with normal hearing sensitivity. Serotonin plays a critical role in some of auditory tasks including startle reflex and prepulse inhibition. Serotonin deficiency can cause some diseases which can coincide with hyperacusis. The aim of the present study was to investigate the probable influence of serotonergic depletion in nucleus accumbens (NAcc) on the startle reflex. The startle reflexes were examined in Wistar rats (n: 48) in different intensities with and without the background noise. The amplitude of startle reflex significantly increased in NAcc-injected rats without background noise, while this difference disappeared in the presence of background noise in all intensities. These data proposed that the injection of 5, 7-Dihydroxytryptamine (5, 7-DHT) into nucleus accumbens will cause hyperacusis-like behavior, and strengthens the possibility of the role of serotonin and nucleus accumbens in hyperacusis.

PMID: 30970270 [PubMed – indexed for MEDLINE]

PMID:
PubMed:30970270

DATE FOUND:
12/24/19 06:06AM

LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/30970270?dopt=Abstract

Top ten hyperacusis research priorities in the UK

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32616-3/fulltext

Top ten hyperacusis research priorities in the UK
Kathryn Fackrell
Linda Stratmann
Toto Anne Gronlund
Derek J Hoare
on behalf of theHyperacusis Priority Setting Partnership Steering Group†
Show footnotes
Published:February 02, 2019DOI:https://doi.org/10.1016/S0140-6736(18)32616-3

Sound Therapies for Tinnitus and Hyperacusis

https://journals.lww.com/thehearingjournal/fulltext/2019/01000/Sound_Therapies_for_Tinnitus_and_Hyperacusis.7.aspx

Sound Therapies for Tinnitus and Hyperacusis

Stapes hypermobility as a possible cause of hyperacusis

https://www.sciencedirect.com/science/article/pii/S0196070918309803

Stapes hypermobility as a possible cause of hyperacusis

Ear Research Foundation, 1901 Floyd Street, Sarasota, FL 34239, United States of America
Received 24 October 2018, Available online 31 October 2018.

Insights from the Third International Conference on Hyperacusis: Causes, Evaluation, Diagnosis, and Treatment

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122267/

http://www.noiseandhealth.org/printarticle.asp?issn=1463-1741;year=2018;volume=20;issue=95;spage=162;epage=170;aulast=Aazh

http://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2018;volume=20;issue=95;spage=162;epage=170;aulast=Aazh

Insights from the Third International Conference on Hyperacusis: Causes, Evaluation, Diagnosis, and Treatment

Hyperacusis – Reddit

hyperacusis – Reddit
A community for those dealing with auditory issues that involve hyperacusis
https://www.reddit.com/r/hyperacusis/

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