www.HyperacusisTreatmentReport.com
https://pubmed.ncbi.nlm.nih.gov/33177407/
https://journals.lww.com/otology-neurotology/Abstract/9000/Within_Subject_Comparisons_of_the_Auditory.95926.aspx
Within-Subject Comparisons of the Auditory Brainstem Response and Uncomfortable Loudness Levels in Ears With and Without Tinnitus in Unilateral Tinnitus Subjects With Normal Audiograms
https://hearinghealthfoundation.org/blogs/investigating-the-interaction-of-auditory-and-pain-pathways
October 6, 2020
Investigating the Interaction of Auditory and Pain Pathways
https://clinicaltrials.gov/ct2/results?cond=Hyperacusis&term=&type=Intr&rslt=&age_v=&gndr=&intr=&titles=&outc=&spons=&lead=&id=&cntry=&state=&city=&dist=&locn=&strd_s=&strd_e=&prcd_s=&prcd_e=&sfpd_s=&sfpd_e=&lupd_s=&lupd_e=&sort=nwst
No Studies found for: Hyperacusis (October 1, 2020)
https://pubs.asha.org/doi/10.1044/2020_AJA-19-00074
https://pubmed.ncbi.nlm.nih.gov/32946248/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200918185324&v=2.11.5
TITLE:
The Content and Quality of Information About Hyperacusis Presented Online
DESCRIPTION:
Purpose Hyperacusis is a disorder characterized by reduced sound tolerance leading to ear pain, emotional distress, and reduced quality of life. Many people with hyperacusis turn to the Internet for information and support from online communities to discuss their condition. The purpose of this study was to assess the content and quality of hyperacusis information presented online. Method The three most used Internet search engines were used to identify relevant websites using the single search…
PMID:
pubmed:32946248
DATE FOUND:
09/18/20 06:53PM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32946248/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200918185324&v=2.11.5
https://www.frontiersin.org/articles/10.3389/fnins.2020.561185/full
https://pubmed.ncbi.nlm.nih.gov/33041759/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201012071633&v=2.12.3
TITLE:
A Novel Mouse Model of Aminoglycoside-Induced Hyperacusis and Tinnitus
DESCRIPTION:
Aminoglycosides (AG) such as amikacin are commonly used in cystic fibrosis patients with opportunistic pulmonary infections including multi-drug resistant mycobacterium tuberculous and non-tuberculous mycobacterium. Unfortunately, this class of drugs is known to cause peripheral damage to the cochlea leading to hearing loss that can fluctuate and become permanent over time or multiple exposures. However, whether amikacin can lead to central auditory dysfunction like hyperacusis (increased…
PMID:
pubmed:33041759
DATE FOUND:
10/12/20 07:16AM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/33041759/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201012071633&v=2.12.3
https://www.frontiersin.org/articles/10.3389/fneur.2020.00966/full
https://pubmed.ncbi.nlm.nih.gov/32982955/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200929171732&v=2.11.5
TITLE:
Investigation of Mechanisms in Bone Conduction Hyperacusis With Third Window Pathologies Based on Model Predictions
DESCRIPTION:
A lumped element impedance model of the inner ear with sources based on wave propagation in the skull bone was used to investigate the mechanisms of hearing sensitivity changes with semi-circular canal dehiscence (SSCD) and alterations of the size of the vestibular aqueduct. The model was able to replicate clinical and experimental findings reported in the literature. For air conduction, the reduction in cochlear impedance due to a SSCD reduces the intra-cochlear pressure at low frequencies…
PMID:
pubmed:32982955
DATE FOUND:
09/29/20 05:17PM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32982955/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200929171732&v=2.11.5
https://www.biorxiv.org/content/10.1101/2020.08.25.264200v2.full
Loud noise exposure differentially affects subpopulations of auditory cortex pyramidal cells
Ingrid Nogueira, Jessica Winne, Thiago Z. Lima, Thawann Malfatti, Richardson N. Leao, View ORCID ProfileKatarina E. Leao
doi: https://doi.org/10.1101/2020.08.25.264200
https://pubmed.ncbi.nlm.nih.gov/32865463/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200831191109&v=2.11.5
TITLE:
The Role of Anti-Endothelial Cell Autoantibodies and Immune Response in Acute Low-Tone Hearing Loss
DESCRIPTION:
CONCLUSION: The results supported that AECAs might wield influence on the short-term outcome of acute low-tone hearing loss (ALHL) treatment. Furthermore, AECA-mediated acute low-frequency hearing loss possibly involved dysregulation of inflammation process and release of cytokines.
PMID:
pubmed:32865463
DATE FOUND:
08/31/20 07:11PM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32865463/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200831191109&v=2.11.5
https://clinicaltrials.gov/ct2/results?cond=Hyperacusis&term=&type=Intr&rslt=&recrs=b&recrs=a&recrs=f&recrs=d&age_v=&gndr=&intr=&titles=&outc=&spons=&lead=&id=&cntry=&state=&city=&dist=&locn=&phase=4&phase=0&phase=1&phase=2&phase=3&rsub=&strd_s=&strd_e=&prcd_s=&prcd_e=&sfpd_s=&sfpd_e=&rfpd_s=&rfpd_e=&lupd_s=&lupd_e=&sort=nwst
https://link.springer.com/article/10.1007%2Fs12070-020-02002-9
https://pubmed.ncbi.nlm.nih.gov/33088781/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201022064939&v=2.12.6
TITLE:
Acoustic Reflexes in Individuals Having Hyperacusis of the Auditory Origin
DESCRIPTION:
Functional role of the acoustic reflex in preventing over stimulation of the inner auditory system by decreasing sound intensity along with the previous reports of acoustic reflex abnormalities in individuals having hyperacusis point towards the involvement of acoustic reflex deficit in the origin of hyperacusis especially when any medical condition leading to hyperacusis is not associated. However this issue remains contradictory owing to limited comprehensive investigation. This study was…
PMID:
pubmed:33088781
DATE FOUND:
10/22/20 06:49AM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/33088781/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20201022064939&v=2.12.6
https://www.mdpi.com/2077-0383/9/8/2412/htm
https://pubmed.ncbi.nlm.nih.gov/32731492/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200731120853&v=2.11.4
TITLE:
Association between Hyperacusis and Tinnitus
DESCRIPTION:
Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18-90 years, and provided information on socio-demographic characteristics, as well as presence of…
PMID:
pubmed:32731492
DATE FOUND:
07/31/20 12:08PM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32731492/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200731120853&v=2.11.4
https://www.wired.com/story/the-world-is-noisy-these-groups-want-to-restore-the-quiet/
The World Is Noisy. These Groups Want to Restore the Quiet
Silence is increasingly scarce, even in national parks. Now, scientists and environmentalists are working to calm the noise for the good of nature—and for us.
https://link.springer.com/chapter/10.1007%2F7854_2020_156
https://pubmed.ncbi.nlm.nih.gov/32653998/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200713031059&v=2.10.1
TITLE:
Functional Neuroanatomy of Salicylate- and Noise-Induced Tinnitus and Hyperacusis
DESCRIPTION:
Tinnitus and hyperacusis are debilitating conditions often associated with aging or exposure to intense noise or ototoxic drugs. One of the most reliable methods of inducing tinnitus is with high doses of sodium salicylate, the active ingredient in aspirin. High doses of salicylate have been widely used to investigate the functional neuroanatomy of tinnitus and hyperacusis. High doses of salicylate have been used to develop novel behavioral methods to detect the presence of tinnitus and…
PMID:
pubmed:32653998
DATE FOUND:
07/13/20 03:11AM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32653998/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200713031059&v=2.10.1
http://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2019;volume=21;issue=100;spage=98;epage=107;aulast=Greenberg
https://pubmed.ncbi.nlm.nih.gov/32655063/
https://pubmed.ncbi.nlm.nih.gov/32655063/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200713131322&v=2.10.1
TITLE:
The sound-sensitive tinnitus index: Psychometric properties of a scale to assess the impact of tinnitus exacerbated by sound
DESCRIPTION:
CONCLUSIONS: As a valid and reliable measure, the SSTI fills an important gap as a clinical and research tool that can differentiate and assess severity and treatment progress in manifestations of combined tinnitus and auditory sensitivity symptoms.
PMID:
pubmed:32655063
DATE FOUND:
07/13/20 01:13PM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32655063/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200713131322&v=2.10.1
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-020-02223-5
https://pubmed.ncbi.nlm.nih.gov/32600446/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200630064428&v=2.9.4
TITLE:
Hyperacusis in children: a scoping review
DESCRIPTION:
CONCLUSION: The information we catalogued on various elements of clinical profile, assessment and management can serve as a stepping stone in future research developing questionnaires for clinical measurement of the impact of hyperacusis on children, and the measurement of treatment related change in clinic and in trials. Positive outcomes were noted by the authors following all of the above treatments; future research must compare these and specify the parameters for optimal results.
PMID:
pubmed:32600446
DATE FOUND:
06/30/20 06:44AM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32600446/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200630064428&v=2.9.4
https://clinicaltrials.gov/ct2/results?cond=Hyperacusis&term=&type=Intr&rslt=&recrs=b&recrs=a&recrs=f&recrs=d&age_v=&gndr=&intr=&titles=&outc=&spons=&lead=&id=&cntry=&state=&city=&dist=&locn=&phase=4&phase=0&phase=1&phase=2&phase=3&rsub=&strd_s=&strd_e=&prcd_s=&prcd_e=&sfpd_s=&sfpd_e=&rfpd_s=&rfpd_e=&lupd_s=&lupd_e=&sort=nwst
No Studies found for: Recruiting, Not yet recruiting, Active, not recruiting, Enrolling by invitation Studies | Interventional Studies | Hyperacusis | Phase Early Phase 1, 1, 2, 3, 4
https://www.sciencedirect.com/science/article/abs/pii/S0378595520302835?via%3Dihub
https://pubmed.ncbi.nlm.nih.gov/32554129/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200623165251&v=2.9.2
TITLE:
Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling
DESCRIPTION:
Moderate intensity sounds can reduce pain sensitivity (i.e., audio-analgesia) whereas intense sounds can induce aural pain, evidence of multisensory interaction between auditory and pain pathways. To explore auditory-pain pathway interactions, we used the tail-flick (TF) test to assess thermal tail-pain sensitivity by measuring the latency of a rat to remove its tail from 52 °C water. In Experiment 1, TF latencies were measured in ambient noise and broadband noise (BBN) presented from 80 to 120…
PMID:
pubmed:32554129
DATE FOUND:
06/23/20 04:55PM
LINK / URL:
https://pubmed.ncbi.nlm.nih.gov/32554129/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1RqsD81NqACU3mBcWXEiLIEwZyWNKyTffLMVHxOddFhfp95AA3&fc=20200623165133&ff=20200623165251&v=2.9.2
https://link.springer.com/article/10.1007%2Fs00405-020-05973-1
https://www.ncbi.nlm.nih.gov/pubmed/32333137?dopt=Abstract
TITLE:
Correlation between recovery time of extended high-frequency audiometry and duration of inflammation in patients with acute otitis media.
DESCRIPTION:
Related Articles
Correlation between recovery time of extended high-frequency audiometry and duration of inflammation in patients with acute otitis media.
Eur Arch Otorhinolaryngol. 2020 Apr 24;:
Authors: Li G, Li T, Liu H, Sun L
Abstract
OBJECTIVES: To explore the rule of extended high-frequency (EHF) audiometry recovery in patients with acute otitis media.
METHODS: From January 2016 to July 2019, patients with acute otitis media in the outpatient department of otology were studied. The diagnosis was made according to the otoscopy and acoustic impedance tests, and antibiotics and other treatment programs were given. The patients were followed up to compare the effects of different recovery time on extended high-frequency audiometry in patients with acute otitis media.
RESULTS: 146 patients with acute otitis media (69 in the left ear and 77 in the right ear) were selected for observation and follow-up. The patients were divided into three groups according to the time from the onset to the disappearance of hyperacusis and earache symptoms: ≤ 5 days group (26 patients, 17.8%), 6-10 days group (74 patients, 50.7%), and > 10 days group (46 patients, 31.5%). The threshold of EHF in the study group was significantly higher than that in the control group in the early stage. According to the study design for follow-up, we found that with the prolongation of the duration of acute otitis media, the extended high frequency of different groups had different changes.
CONCLUSIONS: Our results show that the recovery time of EHF in patients with acute otitis media was later than that of the standard audiogram and was closely related to the course of the disease. This is of great significance for discovering the hidden hearing loss of the patients and taking the treatment plan as soon as possible.
PMID: 32333137 [PubMed – as supplied by publisher]
PMID:
PubMed:32333137
DATE FOUND:
04/26/20 06:04AM
LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/32333137?dopt=Abstract
https://clinicaltrials.gov/ct2/results?cond=Hyperacusis&term=&type=Intr&rslt=&age_v=&gndr=&intr=&titles=&outc=&spons=&lead=&id=&cntry=&state=&city=&dist=&locn=&strd_s=&strd_e=&prcd_s=&prcd_e=&sfpd_s=&sfpd_e=&lupd_s=&lupd_e=&sort=nwst
No Studies found for: Hyperacusis (January 20, 2020)
https://clinicaltrials.gov/ct2/show/NCT03666676
Hearing Study: Sensitivity to Features of Speech Sounds
Study Description
Brief Summary:
The purpose of this study is to better understand the sensitivity of listeners to the fast changes in frequency or amplitude of sounds that occur in speech. The investigators are studying ways to manipulate these aspects of sounds in an effort to make speech sounds more clear.
Condition or disease Intervention/treatment Phase
Hearing Loss, Sensorineural
Other: Signal processing to improve intelligibility
Not Applicable
Detailed Description:
The investigators will test listeners with normal hearing or with mild or moderate hearing loss. Tests will first focus on sensitivity to changes in fast changes in amplitude (loudness) or frequency (pitch) in sounds. Then the investigators will test the intelligibility of synthetic vowels and syllables in which these “chirps” are manipulated. Finally, the investigators will test intelligibility of words in noise while manipulating sounds in an effort to improve clarity.
Study Design
Go to sections
Study Type : Interventional (Clinical Trial)
Estimated Enrollment : 200 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Auditory Processing of Complex Sounds – Sensitivity to Chirps
Actual Study Start Date : January 15, 2020
Estimated Primary Completion Date : November 30, 2023
Estimated Study Completion Date : November 30, 2023
Highlights from the 2019 ARO Research Conference
https://pubs.asha.org/doi/10.1044/2019_AJA-19-0045
https://www.ncbi.nlm.nih.gov/pubmed/31770010
Patients’ Perspectives About the Acceptability and Effectiveness of Audiologist-Delivered Cognitive Behavioral Therapy for Tinnitus and/or Hyperacusis Rehabilitation
https://www.tinnitustalk.com/podcast/wp-content/uploads/2019/12/transcript-tinnitus-talk-podcast-ep-08-bryan-pollard.pdf
https://journals.sagepub.com/doi/abs/10.1177/0003489419892997?journalCode=aora
https://pubmed.ncbi.nlm.nih.gov/31786960-efficacy-of-multi-modal-migraine-prophylaxis-therapy-on-hyperacusis-patients/
Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients
PMID: 31786960
Abstract
Objectives:
To evaluate the efficacy of a multi-modal migraine prophylaxis therapy for patients with hyperacusis.
Methods:
In a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen (nortriptyline, verapamil, topiramate, or a combination thereof) as well as lifestyle and dietary modifications. Pre- and post-treatment average loudness discomfort level (LDL), hyperacusis discomfort level measured by a visual analogue scale (VAS), and scores on the modified Khalfa questionnaire for severity of hyperacusis were compared.
Results:
Twenty-two of the 25 patients (88%) reported subjective resolution of their symptoms following treatment. Post-treatment audiograms showed significant improvement in average LDL from 81.3 ± 3.2 dB to 86.4 ± 2.6 dB (P < .001), indicating increased sound tolerability. The VAS discomfort level also showed significant improvement from a pre-treatment average of 7.7 ± 1.1 to 3.7 ± 1.6 post-treatment (P < .001). There was also significant improvement in the average total score on modified Khalfa questionnaire (32.2 ± 3.6 vs 22.0 ± 5.7, P < .001).
Conclusions:
The majority of patients with hyperacusis demonstrated symptomatic improvement from migraine prophylaxis therapy, as indicated by self-reported and audiometric measures. Our findings indicate that, for some patients, hyperacusis may share a pathophysiologic basis with migraine disorder and may be successfully managed with multimodal migraine prophylaxis therapy.
https://www.sciencedirect.com/science/article/abs/pii/S0306452219306554?via%3Dihub
https://pubmed.ncbi.nlm.nih.gov/31669363-noise-induced-loudness-recruitment-and-hyperacusis-insufficient-central-gain-in-auditory-cortex-and-amygdala/
Noise-Induced loudness recruitment and hyperacusis: Insufficient central gain in auditory cortex and amygdala
https://www.sciencedirect.com/science/article/pii/S0196070919309408?via%3Dihub
Minimally invasive surgery for the treatment of hyperacusis: New technique and long term results
https://journals.lww.com/thehearingjournal/Fulltext/2019/10000/Clinical_Advancements_for_Managing_Hyperacusis.4.aspx
Clinical Advancements for Managing Hyperacusis with Pain
Pollard, Bryan
Author Information
Mr. Pollard is the founder of Hyperacusis Research, a non-profit that focuses on uncovering the mechanisms of hyperacusis to eliminate noise-induced pain. He is also a manager and technical problem-solver in engineering disciplines associated with complex processes.
https://www.tandfonline.com/doi/abs/10.1080/14992027.2019.1660812?journalCode=iija20
https://www.ncbi.nlm.nih.gov/pubmed/31498009?dopt=Abstract
TITLE:
A review of auditory gain, low-level noise and sound therapy for tinnitus and hyperacusis.
DESCRIPTION:
Related Articles
A review of auditory gain, low-level noise and sound therapy for tinnitus and hyperacusis.
Int J Audiol. 2019 Sep 09;:1-11
Authors: Sheppard A, Stocking C, Ralli M, Salvi R
Abstract
Objective: This article reviews: (1) the evidence related to enhanced central gain as a potential mechanism for the generation of tinnitus and hyperacusis, (2) the neuroplastic changes induced by prolonged, low-level sound stimulation and (3) the clinical effectiveness of various sound therapies and amplification for the treatment of tinnitus and hyperacusis. Design: General literature review. Study sample: Peer-reviewed articles related to auditory neural gain, prolonged low-level noise exposure and effectiveness of sound therapy. Results: A large body of literature exists supporting the enhanced neural gain model of tinnitus and hyperacusis. Neuroplastic changes associated with prolonged low-level noise show evidence of reversing enhanced neural gain, which should theoretically reduce percepts of tinnitus and/or hyperacusis. However, the available clinical evidence assessing the efficacy of sound therapy to reduce tinnitus or hyperacusis lacks controlled clinical trials to accurately assess the effectiveness of sound therapy. Conclusions: The available literature from basic science studies supports the neural gain model of tinnitus and hyperacusis, which conceivably should be effectively managed with sound therapy. However, well-controlled clinical trials are needed before conclusions can be made on the effectiveness of sound therapy for tinnitus and hyperacusis.
PMID: 31498009 [PubMed – as supplied by publisher]
PMID:
PubMed:31498009
DATE FOUND:
09/23/19 11:58AM
LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/31498009?dopt=Abstract
https://www.dailycommercial.com/news/20190726/sarasota-doctor-develops-treatment-for-hyperacusis
Sarasota doctor develops treatment for hyperacusis
https://www.ejao.org/journal/view.php?doi=10.7874/jao.2018.00514
https://pubmed.ncbi.nlm.nih.gov/30292765-testing-the-central-gain-model-loudness-growth-correlates-with-central-auditory-gain-enhancement-in-a-rodent-model-of-hyperacusis/?from_term=%22Auditory+Cortex%2Fdrug+effects%22%5BMeSH%5D&from_sort=date&from_sort_order=&from_size=200&from_pos=2
https://www.sciencedirect.com/science/article/abs/pii/S0306452218306419?via%3Dihub
Neuroscience, 407, 93-107
2019 May 21
Testing the Central Gain Model: Loudness Growth Correlates With Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis
Benjamin D Auerbach 1, Kelly Radziwon 2, Richard Salvi 2
Affiliations
Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY 14214, USA. Electronic address: bda5@buffalo.edu.
PMID: 30292765 DOI: 10.1016/j.neuroscience.2018.09.036
Abstract
The central gain model of hyperacusis proposes that loss of auditory input can result in maladaptive neuronal gain increases in the central auditory system, leading to the over-amplification of sound-evoked activity and excessive loudness perception. Despite the attractiveness of this model, and supporting evidence for it, a critical test of the central gain theory requires that changes in sound-evoked activity be explicitly linked to perceptual alterations of loudness. Here we combined an operant conditioning task that uses a subject’s reaction time to auditory stimuli to produce reliable measures of loudness growth with chronic electrophysiological recordings from the auditory cortex and inferior colliculus of awake, behaviorally-phenotyped animals. In this manner, we could directly correlate daily assessments of loudness perception with neurophysiological measures of sound encoding within the same animal. We validated this novel psychophysical-electrophysiological paradigm with a salicylate-induced model of hearing loss and hyperacusis, as high doses of sodium salicylate reliably induce temporary hearing loss, neural hyperactivity, and auditory perceptual disruptions like tinnitus and hyperacusis. Salicylate induced parallel changes to loudness growth and evoked response-intensity functions consistent with temporary hearing loss and hyperacusis. Most importantly, we found that salicylate-mediated changes in loudness growth and sound-evoked activity were correlated within individual animals. These results provide strong support for the central gain model of hyperacusis and demonstrate the utility of using an experimental design that allows for within-subject comparison of behavioral and electrophysiological measures, thereby making inter-subject variability a strength rather than a limitation.
Keywords: auditory reaction time; central gain enhancement; hyperacusis; local field potentials; sodium salicylate.
Copyright © 2018. Published by Elsevier Ltd.
https://www.ncbi.nlm.nih.gov/pubmed/30970270?dopt=Abstract
https://www.sciencedirect.com/science/article/abs/pii/S0304394019300527?via%3Dihub
TITLE:
Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?
DESCRIPTION:
Related Articles
Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?
Neurosci Lett. 2019 07 13;705:246-250
Authors: Farahani S, Nasirinezhad F, Danyali S, Jalaei S, Shahbazi A, Karimi M, Mokrian H
Abstract
Hyperacusis may be defined as diminishing tolerance to moderate and high intensity sounds in people with normal hearing sensitivity. Serotonin plays a critical role in some of auditory tasks including startle reflex and prepulse inhibition. Serotonin deficiency can cause some diseases which can coincide with hyperacusis. The aim of the present study was to investigate the probable influence of serotonergic depletion in nucleus accumbens (NAcc) on the startle reflex. The startle reflexes were examined in Wistar rats (n: 48) in different intensities with and without the background noise. The amplitude of startle reflex significantly increased in NAcc-injected rats without background noise, while this difference disappeared in the presence of background noise in all intensities. These data proposed that the injection of 5, 7-Dihydroxytryptamine (5, 7-DHT) into nucleus accumbens will cause hyperacusis-like behavior, and strengthens the possibility of the role of serotonin and nucleus accumbens in hyperacusis.
PMID: 30970270 [PubMed – indexed for MEDLINE]
PMID:
PubMed:30970270
DATE FOUND:
12/24/19 06:06AM
LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/30970270?dopt=Abstract
https://journals.lww.com/thehearingjournal/fulltext/2019/01000/Sound_Therapies_for_Tinnitus_and_Hyperacusis.7.aspx
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Ear Research Foundation, 1901 Floyd Street, Sarasota, FL 34239, United States of America
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